The Dow Jones Industrial Average finished down 4.15% at 23,860.46, the S&P 500 fell 3.75% to 2,581.00, and the Nasdaq 100lost 4.19% to settle at 6,306.10.
Stocks initially started the day with a slight bid in the wake of the latest set of initial jobless claims, but that quickly evaporated.
As expected, the UK's Monetary Policy Committee kept all its main policy settings unchanged, but according to analysts rate-setters may have opened the door to a hike in the bank rate for as soon as its meeting in May.
“Governor Carney said the BoE needed to hike earlier and more than was priced,” said analysts at Bank of America-Merrill Lynch.
“So we now expect a 25bp bank rate hike in May and another in February 2019.”
The analysts did caveat that such a scenario was “highly conditional”, however, adding that if Brexit transition talks dragged past March or PMIs remained where they are, the would have to reconsider.
Back in the US, the weekly unemployment claims data revealed a 9,000-head decline to 221,000 for the week to 3 February, to stand just above 45-year lows reported in mid-January.
Economists had predicted the number of claims to rise to somewhere in the vicinity of 232,000.
And in Fedspeak action, Philly Fed president Patrick Harker said he was open to hiking interest rates at the March meeting of the Federal Open Market Committee.
However, Harker's forecasts still called for only two hikes in 2018.
He reportedly also called into question the outlook for inflation, saying that it might firm - or not.
Minneapolis Fed President Neel Kashkari said the US central bank was "a long way away" from raising interest rates due to further inflation caused by higher labour costs.
Kashkari also said the January jobs report was actually only ‘mixed’ in terms of wage growth.
“If you dig beneath the surface, wages went up a little but hours went down,” he said.
“And so it was not actually a resoundingly strong report in terms of the outlook for wages.
“We need to see that wages are going to go up consistently across the board.”
Market participants were also keeping an eye on politics after Senate leaders announced a two-year budget deal late on Wednesday that still needed to pass the House.
The deal, outlined by majority leader Mitch McConnell and minority leader Chuck Schumer, was slammed by conservatives and would increase military and non-defence spending by $300bn and add more than $80bn in disaster relief.
According to analysts, news of the deal was the main factor behind the earlier rise in US bond yields.
On the corporate front, shares in Tesla lost 8.63% after the electric carmaker posted its biggest ever quarterly loss less than 24 hours after Elon Musk chose to shoot his car into space.
Tesla reported a loss of $675.4m, compared to a loss of $121m in the same period a year ago.
Twenty-First Century Fox was also in focus, trading 4.51% lower after its quarterly earnings and revenue beat analysts' expectations.
Revenue for the second quarter came in at $8.04bn versus expectations of $7.94bn, while adjusted earnings per share were 42 cents versus a forecast of 38 cents.
Social media giant Twitter posted its first net quarterly profit in history on Thursday, sending its shares 12.15% higher.
The firm said rising sales of video advertising space across the microblog had come alongside seriously slashed expenses, swinging the President's personal soapbox to a net profit of $91.1m for its fourth trading quarter – a 154% improvement on the previous year's $167.1m loss.
Shares in cigarette maker Philip Morris picked up 1.55%, despite the company reporting an earnings-per-share figure that fell short of analyst expectations and a net income of $694m for the quarter, down 60% from the year-ago quarter.
Dow Jones - Risers
Exxon Mobil Corp. (XOM) $76.07 -1.13%
Procter & Gamble Co. (PG) $80.22 -1.98%
Merck & Co. Inc. (MRK) $54.73 -2.06%
Chevron Corp. (CVX) $112.30 -2.59%
Walmart Inc. (WMT) $100.02 -2.75%
Apple Inc. (AAPL) $155.15 -2.75%
Walt Disney Co. (DIS) $101.35 -3.26%
Coca-Cola Co. (KO) $43.10 -3.28%
Dowdupont Inc. (DWDP) $68.21 -3.39%
United Technologies Corp. (UTX) $127.48 -3.40%
Dow Jones - Fallers
American Express Co. (AXP) $88.34 -5.63%
Intel Corp. (INTC) $42.75 -5.42%
Caterpillar Inc. (CAT) $145.99 -5.41%
Boeing Co. (BA) $329.66 -5.30%
Home Depot Inc. (HD) $181.22 -5.26%
General Electric Co. (GE) $14.45 -5.25%
Microsoft Corp. (MSFT) $85.01 -5.13%
Travelers Company Inc. (TRV) $135.01 -5.02%
Visa Inc. (V) $113.86 -4.84%
Nike Inc. (NKE) $62.49 -4.78%
S&P 500 - Risers
Viacom Inc. Class B (VIAB) $32.71 7.21%
Fiserv Inc. (FISV) $133.05 3.00%
Kellogg Co. (K) $65.98 2.76%
Cardinal Health Inc. (CAH) $66.63 2.29%
Philip Morris International Inc. (PM) $100.39 1.53%
Southwestern Energy Co. (SWN) $3.65 1.11%
Tyson Foods Inc. (TSN) $73.72 0.74%
Omnicom Group Inc. (OMC) $75.92 0.70%
Essex Prty Trust Inc. (ESS) $218.16 0.22%
Interpublic Group of Companies Inc. (IPG) $21.34 0.19%
S&P 500 - Fallers
Hanesbrands Inc. (HBI) $19.57 -10.88%
Goodyear Tire & Rubber Co. (GT) $30.75 -8.13%
Newfield Exploration Co (NFX) $26.39 -7.54%
Alexion Pharmaceuticals Inc. (ALXN) $108.47 -7.41%
Robert Half International Inc. (RHI) $52.26 -7.04%
Allstate Corp (The) (ALL) $90.06 -7.03%
Prudential Fincl Inc. (PRU) $103.38 -7.01%
Teradata Corp. (TDC) $37.29 -6.98%
Frontier Communications Co. (FTR) $7.15 -6.78%
Synchrony Financial (SYF) $34.98 -6.72%
Nasdaq 100 - Risers
Fiserv Inc. (FISV) $133.05 3.00%
Mercadolibre Inc. (MELI) $345.31 0.51%
O'Reilly Automotive Inc. (ORLY) $252.22 0.06%
Check Point Software Technologies Ltd. (CHKP) $98.20 -0.84%
Starbucks Corp. (SBUX) $53.77 -1.27%
Liberty Global plc Series C (LBTYK) $33.86 -1.63%
Liberty Global plc Series A (LBTYA) $35.10 -1.71%
Cognizant Technology Solutions Corp. (CTSH) $75.16 -1.78%
Fastenal Co. (FAST) $52.15 -2.05%
Maxim Integrated Products Inc. (MXIM) $55.60 -2.13%
Nasdaq 100 - Fallers
Take-Two Interactive Software Inc. (TTWO) $103.51 -11.67%
Tesla Inc (TSLA) $315.23 -8.63%
Alexion Pharmaceuticals Inc. (ALXN) $108.47 -7.41%
NetEase Inc. Ads (NTES) $289.61 -6.28%
Xilinx Inc. (XLNX) $62.82 -6.20%
Applied Materials Inc. (AMAT) $45.75 -6.04%
Align Technology Inc. (ALGN) $220.71 -5.81%
Workday, Inc. (WDAY) $110.97 -5.77%
Hasbro Inc (HAS) $96.48 -5.62%
Gilead Sciences Inc. (GILD) $78.22 -5.49%
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